In dem nachfolgend beschriebenen Forschungsprojekt wurden spezifische neuropsychologische Test- und Diagnostikverfahren bei Personen mit dementiellen Erkrankungsprozessen eingesetzt. Aus den Untersuchungsergebnissen konnte ersichtlich werden, dass der Einsatz spezifischer neuropsychologischer Testverfahren geeignet ist, um eine Differenzierung zwischen Störungen als Folge einer Alzheimererkrankung versus einer frontotemporalen Demenz zu leisten. Hieraus konnte abgeleitet werden, dass Personen mit Alzheimererkrankung eher Gedächtnisdefizite aufzeigten, wohingegen Personen mit frontotemporalen Demenzformen eher sprachliche Einschränkungen sowie Störungen der exekutiven Funktionsfähigkeiten aufzeigten.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479762/
References/ Literaturhinweise
Karageorgiou E, Miller BL. Frontotemporal lobar degeneration: a clinical approach. Seminars in neurology. 2014;34(2):189–201. [PubMed] [Google Scholar]
Woolley JD, Khan BK, Murthy NK, Miller BL, Rankin KP. The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease. The Journal of clinical psychiatry. 2011;72(2):126–133. [PMC free article] [PubMed] [Google Scholar]
Weintraub S, Wicklund AH, Salmon DP. The neuropsychological profile of Alzheimer disease. Cold Spring Harbor perspectives in medicine. 2012;2(4):a006171. [PMC free article] [PubMed] [Google Scholar]
Bozeat S, Gregory CA, Ralph MA, Hodges JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? Journal of neurology, neurosurgery, and psychiatry. 2000;69(2):178–186. [PMC free article] [PubMed] [Google Scholar]
Kramer JH, Jurik J, Sha SJ, et al. Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 2003;16(4):211–218. [PubMed] [Google Scholar]
Pachana NA, Boone KB, Miller BL, Cummings JL, Berman N. Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia. Journal of the International Neuropsychological Society : JINS. 1996;2(6):505–510. [PubMed] [Google Scholar]
Lindau M, Almkvist O, Kushi J, et al. First symptoms--frontotemporal dementia versus Alzheimer's disease. Dementia and geriatric cognitive disorders. 2000;11(5):286–293. [PubMed] [Google Scholar]
Gregory CA, Orrell M, Sahakian B, Hodges JR. Can frontotemporal dementia and Alzheimer's disease be differentiated using a brief battery of tests? International journal of geriatric psychiatry. 1997;12(3):375–383. [PubMed] [Google Scholar]
Perry RJ, Hodges JR. Differentiating frontal and temporal variant frontotemporal dementia from Alzheimer's disease. Neurology. 2000;54(12):2277–2284. [PubMed] [Google Scholar]
Forman MS, Farmer J, Johnson JK, et al. Frontotemporal dementia: clinicopathological correlations. Annals of neurology. 2006;59(6):952–962. [PMC free article] [PubMed] [Google Scholar]
Grossman M, Libon DJ, Forman MS, et al. Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia. Archives of neurology. 2007;64(11):1601–1609. [PubMed] [Google Scholar]
Rascovsky K, Salmon DP, Hansen LA, Thal LJ, Galasko D. Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease. Neuropsychology. 2007;21(1):20–30. [PubMed] [Google Scholar]
Rascovsky K, Salmon DP, Ho GJ, et al. Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD. Neurology. 2002;58(12):1801–1808. [PubMed] [Google Scholar]
Weintraub S, Salmon D, Mercaldo N, et al. The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery. Alzheimer disease and associated disorders. 2009;23(2):91–101. [PMC free article] [PubMed] [Google Scholar]
Beekly DL, Ramos EM, van Belle G, et al. The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database. Alzheimer disease and associated disorders. 2004;18(4):270–277. [PubMed] [Google Scholar]
Harrell FE. Regression Modeling Strategies. New York: Springer; 2001. [Google Scholar]
Diehl J, Kurz A. Frontotemporal dementia: patient characteristics, cognition, and behaviour. International journal of geriatric psychiatry. 2002;17(10):914–918. [PubMed] [Google Scholar]
Hutchinson AD, Mathias JL. Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review. Journal of neurology, neurosurgery, and psychiatry. 2007;78(9):917–928. [PMC free article] [PubMed] [Google Scholar]
Gregory CA, Hodges JR. Clinical features of frontal lobe dementia in comparison to Alzheimer's disease. Journal of neural transmission Supplementum. 1996;47:103–123. [PubMed] [Google Scholar]
Rahman S, Sahakian BJ, Hodges JR, Rogers RD, Robbins TW. Specific cognitive deficits in mild frontal variant frontotemporal dementia. Brain : a journal of neurology. 1999;122(Pt 8):1469–1493. [PubMed] [Google Scholar]
Thompson JC, Stopford CL, Snowden JS, Neary D. Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2005;76(7):920–927.[PMC free article] [PubMed] [Google Scholar]